To initiate cooperation than their Japanese counterparts Casson, 1991; Dunning, 1995 ; . The reason most often evoked is that Japanese firms exhibit a higher level of trust Sako and Helper, 1998 ; . However, a study by Yamagashi and Yamagashi 1994 ; retaining the same definition of trust as used in this paper, finds that the level of trust among Japanese is lower than among Americans. Furthermore, Hagan and Choe 1998 ; put forward the notion that trust in Japan is simply a social norm that emerges given the system of sanctions and punishments associated with cheating on commitments. With respect to the above literature, whatever the reasons for the existing levels of trust whether or not they are due to a social system of sanctions ; , the present article points out that it is the nature of firms, their levels of trust and the levels of knowledge spillovers that determines whether or not they will cooperate. If the payoffs to cooperation are as in the game considered in the article, then populations with a higher proportion of opportunist firms will be more predisposed to initiate cooperation because they need less trust than non-opportunist firms to initiate cooperation. This is of course at loggerheads with the notion that `trusting firms' are more prone to initiate cooperation. Therefore, if cooperation is more prevalent in a region, it could be either because the levels of trust are high or because the proportion of trusting firms or non-opportunist firms is low. More than trust, it could be the potential exploitation of opportunism that stimulates cooperation in R&D. Finally, the article also shows that under certain conditions the potential manifestation of opportunism need not pose a threat to the realization of satisfactory cooperation. This of course, calls for a further examination of not only why R&D cooperation is initiated, but also why it breaks down with or without the manifestation of opportunism. This paper has its own limitations too. It does not discuss the welfare implications of the model's results in depth. The structure of the game, including the payoff structure, is such that an opportunist always cheats at equilibrium. This does not need to be true of all games. Extensions can explore the.
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Earnings before minority interest and income taxes of $4, 369 million in 2003 increased from $3, 185 million in 2002 primarily due to increased sales, which were partially offset by increased advertising and product spending on new and existing in-line products. Earnings before minority interest and income taxes in 2002 and 2001 were $3, 185 million and $1, 857 million, respectively. The increase in 2002 is mainly due to lower earnings in 2001 as a result of the write-off of $2, 772 million of acquired in-process research and development. Earnings in 2002 were unfavorably affected by higher sales of lower margin products, and the full year impact of generic competition on Glucophage IR, TAXOL and BuSpar in the United States. Oncology Therapeutics Network In 2003, OTN sales were $2, 241 million, an increase of 18% over the prior year due to volume growth and manufacturers' price changes. In 2002, sales increased 33% to $1, 900 million from $1, 433 million in 2001. OTN sales accounted for 11%, 10%, and 8% of the Company's net sales in 2003, 2002 and 2001, respectively. Earnings before minority interest and income taxes of $14 million in 2003 decreased slightly from $15 million in 2002 and $16 million in 2001 due to margin erosion and investments in system infrastructure. Nutritionals In 2003, Nutritionals sales were $2, 023 million, an increase of 11% over 2002. This increase was due to a 7% increase in volume and a 5% price increase, partially offset by a 1% decrease due to foreign exchange. International sales increased 9%, including a 2% unfavorable foreign exchange impact, to $938 million from $862 million in 2002. Domestic sales increased 13% to $1, 085 million from $959 million in 2002. Worldwide children's nutritionals sales increased 10%, including a 5% unfavorable foreign exchange impact, to $421 million in 2003 from $383 million in 2002, as a result of a 29% increase in sales of Enfagrow, primarily throughout the Pacific region, to $156 million in 2003. Worldwide infant formula sales increased 10% to $1, 284 million in 2003 with no significant foreign exchange impact ; , primarily due to increased sales of Enfamil, the Company's largest-selling infant formula. International sales of Enfamil increased 5% to $239 million in 2003 from $228 million in 2002 with no significant foreign exchange impact ; and domestic sales of Enfamil increased 10% to $569 million in 2003 from $518 million in 2002. Mead Johnson Nutritionals Mead Johnson ; continues to be the leader in the U.S. infant formula market. In 2002, Nutritionals sales remained consistent with 2001 sales at and celexa.
Outpatient procedures performed, medical certificate given, medication prescribed up to 8, but only a maximum of 5 items were analysed ; , and referral made. The sources of payment were originally coded as cash out-of-pocket payment by patients ; , panel patients or clinics claiming the consultation fee from the employers ; and managed care payment is paid via a managed care organisation, primarily by capitation ; . Panel system and managed care were recoded as "non-cash" as subsequent analyses showed that they are similar for patient's demographic characteristics, morbidity and process of care. Data analysis We used SPSS version 10 for data entry and analysis. The morbidity data was coded using ICPC-2, 7 ; this was facilitated by using ICPC-2 plus Demonstrator courtesy of Family Medicine Research Unit, Dept of General Practice, University of Sydney ; . Categorical and continuous variables were compared using c2-test and t-test respectively. Statistical significance is set at p 0.05. Multinomial logistic regression was used to look for independent association between age, Chinese ethnicity, fever and sore throat and antibiotic prescription. Results One hundred and twenty five clinics returned 3481 complete Data Encounter Forms. Encounters with ICPC Diagnosis codes R74, R75 and R76 were classified as URTI Table 1 ; . We have classified as URTI in 11 encounters where diagnoses were recorded as symptoms only R21 and R25 ; after verifying the chief complaints recorded were consistent with URTI. Thus the number % ; of encounter was 940 27.0% ; . Table 1: ICPC diagnosis codes of URTI encounters.
REDUCED SLEEP IS A RISK FACTOR FOR WEIGHT GAIN Patel SR, 1 Malhotra A, 2 Gottlieb DJ, 3 White DP, 2 Hu FB2 1 ; Case Western Reserve University, Cleveland, OH, USA, 2 ; Brigham and Women's Hospital, Boston, MA, USA, 3 ; Boston University, Boston, MA, USA Introduction : Recent physiologic research suggests sleep restriction has important metabolic effects that may predispose to weight gain. We sought to investigate the association between self-reported usual sleep duration and subsequent weight gain. Methods : Women in the Nurses Health Study who responded to a question about habitual sleep duration in 1986 were followed for the subsequent 16 years. Information regarding weight and important covariates were obtained via questionnaire every 2 years. Multivariate linear regression and Cox proportional hazards models were used to assess sleep duration as a predictor of weight gain. Results : Data from 68, 183 women were analyzed. In analyses adjusted for age and baseline body mass index BMI ; , women sleeping 5 hours or less per night gained 1.04 kg 95% CI [0.39-1.69] ; more than those sleeping 7 hours over 16 years and women sleeping 6 hours gained 0.68 kg 95% CI [0.39-0.97] ; more. The relative risks of a 15 more weight gain were 1.32 95% CI [1.19-1.47] ; and 1.12 95% CI [1.06-1.19] ; for those sleeping 5 and 6 hours respectively. The relative risks for development of obesity BMI 30 kg m2 ; were 1.15 95% CI [1.04-1.26] ; and 1.06 95% CI [1.01-1.11] ; . These associations remained significant after inclusion of important covariates and were not affected by adjustment for physical activity or dietary consumption. Conclusion : Short sleep duration is an independent predictor of future weight gain and incident obesity. Further research is needed to understand the mechanisms by which sleep duration may affect weight. Support optional ; : NIH DK58845, P30 DK46200, CA87969 and HL081385 and the AHA and cephalexin.
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